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A Mother's Diet and its Impact on Future Generations: A Fascinating Genetic Insight

A Mother's Diet and its Impact on Future Generations: A Fascinating Genetic Insight

Irene Rojas |

Mothers-to-be are often bombarded with advice on what to eat and what to avoid during pregnancy. But did you know that what a mother eats might not only affect her child but also her grandchildren? A new study from Monash University reveals a fascinating connection between a mother's diet and the brain health of subsequent generations.

The Study: Apples, Herbs, and Brain Health

Published in Nature Cell Biology, the researchers at Monash Biomedicine Discovery Institute have used genetic models to study the effect of a mother's diet on her offspring's brain health. Specifically, they found that a molecule found in apples and various herbs could significantly impact the brain's functionality.

They used roundworms, whose genes are often conserved in humans, to analyze this effect. This has allowed them to gain insights that might be applicable to human biology.

The Key Discovery: Ursolic Acid

The molecule in question is ursolic acid, present in apples and herbs like basil, rosemary, thyme, oregano, and sage. Researchers found that this molecule helped reduce the fragility of axons - the 'communication cables' in the brain necessary for proper functionality.

The way this works is particularly interesting. Ursolic acid causes a specific gene to activate a particular type of fat, known as a sphingolipid. This fat prevented the axon's fragility and improved its overall health. The lipid has been shown to be inherited and protects the axons of two subsequent generations.

What Does This Mean for Humans?

While these results are promising, they still need to be confirmed in humans. However, the study does provide strong evidence to support a healthy diet during pregnancy for optimal brain development.

It implies that a mother's consumption of certain foods, like apples and herbs containing ursolic acid, could have long-term benefits that extend to her grandchildren. This novel discovery emphasizes the importance of nutrition, not just for immediate health but for the well-being of future generations.


The Monash University study opens a new dimension in our understanding of genetics and nutrition. While there's still more research to be done, especially in human subjects, the insights provided are truly groundbreaking.

So next time you're reaching for a snack, remember: the choices you make might not only impact you but your future generations as well. Choose wisely!